http://www.kadhoai.com.cn 2026-04-07 20:16:38 來源:生物穀
新式的超靈敏生物傳感器,可以對癌症和病人個性化用藥涉及的生化反應進行早期及時檢測 (Credit: Purdue University image)
近jin日ri,來lai自zi普pu渡du大da學xue的de研yan究jiu者zhe發fa明ming了le一yi種zhong超chao靈ling敏min的de生sheng物wu傳chuan感gan器qi,可ke以yi對dui癌ai症zheng和he病bing人ren個ge性xing化hua用yong藥yao涉she及ji的de生sheng化hua反fan應ying進jin行xing早zao期qi及ji時shi檢jian測ce。這zhe種zhong生sheng物wu傳chuan感gan器qi結jie合he了le兩liang種zhong不bu同tong類lei型xing的de傳chuan感gan器qi,比bi一yi般ban的de傳chuan感gan器qi敏min感gan度du高gao數shu百bai倍bei。研yan究jiu者zheMuhammad A.Alambiaoshi,yibanlaijiang,dandudebutongleixingdeshengwuchuanganqidejianceminganxinghuiyouyidingxianzhi,danshiruguojiangqijieheqilai,jiuhuikefuqiminganxingshangdexianzhi。xiangguanyanjiuchengguokandengzaile5月14日的國際雜誌PNAS上。
這種名叫Flexure-FET的(de)生(sheng)物(wu)傳(chuan)感(gan)器(qi)結(jie)合(he)了(le)一(yi)個(ge)機(ji)械(xie)傳(chuan)感(gan)器(qi)和(he)電(dian)子(zi)傳(chuan)感(gan)器(qi),前(qian)者(zhe)可(ke)以(yi)識(shi)別(bie)出(chu)生(sheng)物(wu)活(huo)性(xing)分(fen)子(zi)的(de)分(fen)子(zi)量(liang)以(yi)及(ji)尺(chi)寸(cun),電(dian)子(zi)傳(chuan)感(gan)器(qi)可(ke)以(yi)利(li)用(yong)電(dian)荷(he)來(lai)對(dui)分(fen)子(zi)進(jin)行(xing)鑒(jian)定(ding),這(zhe)種(zhong)新(xin)式(shi)傳(chuan)感(gan)器(qi)可(ke)以(yi)對(dui)帶(dai)電(dian)荷(he)和(he)不(bu)帶(dai)電(dian)荷(he)的(de)生(sheng)物(wu)分(fen)子(zi)進(jin)行(xing)檢(jian)測(ce),比(bi)一(yi)般(ban)的(de)傳(chuan)感(gan)器(qi)的(de)檢(jian)測(ce)範(fan)圍(wei)更(geng)廣(guang)。Flexure-FET有兩種潛在的應用前景,1.個體化醫療,可以精確記錄病人的蛋白質和DNA信息,並且提供更為精確的診斷和治療建議;2.癌症和其它疾病的早期檢測。

在早期癌症診斷中,Flexure-FET可以在疾病被其它檢測設備檢測到之前,對疾病前期少量的DNA片段和蛋白質進行必要可能的檢測,傳感器的機械部分是一個振動懸臂(和微小跳水板類似的矽片),在zai懸xuan臂bi底di下xia的de是shi一yi個ge電dian晶jing片pian,是shi傳chuan感gan器qi的de電dian子zi部bu分fen。在zai其qi它ta的de機ji械xie傳chuan感gan器qi中zhong,激ji光guang可ke以yi測ce定ding振zhen動dong頻pin率lv和he懸xuan臂bi的de偏pian斜xie度du,並bing且qie依yi賴lai生sheng物wu分fen子zi的de類lei型xing而er改gai變bian,然ran而er這zhe種zhong新xin式shi傳chuan感gan器qi僅jin僅jin使shi用yong電dian晶jing片pian來lai測ce定ding振zhen動dong頻pin率lv和he懸xuan臂bi的de偏pian斜xie度du。
zhezhongxinshideshengwuchuanganqikeyitongguotiaozhengzhengtijiegoulaishidejiancelingmindudadaozuida,xuanbishiyongdianchanglaijinxingqianyinde,erdianjingpianyilaiyudianyalaitiaojieqilingmindu,yanjiuzheAlambiaoshi,nikeyiyongrenheninengxiangdaodefenzilaijinxingjiance,chuanganqidouhuigeichunizuijingquedecedingjieguo。zhexiangxinjishudeguanjianchuangxindianzaiyuxiaochulecanbidianjidexianzhi,ranerchangguideshengwuchuanganqiqueshixuyaocanbidianjide。zuihouyanjiuzhebiaoshi,xiaochulecanbidianjikeyishideshengwuchuanganqigengjiaxiaoxinghua,erqieyinqidichengbenheshiyongxing,duiyuguangdayishenglaishuogengweishiyongbingqiekexing。(生物穀:T.Shen編譯)